Skin aging affects millions of patients every year, and for women, hormonal changes related to menopause can significantly accelerate visible changes in skin texture, hydration, and elasticity.
Research shows that estrogen-deficient skin can experience up to a 30% decrease in collagen within five years of menopause, contributing to dryness, thinning, and fine lines.*
For prescribers seeking a clinically differentiated option to support estrogen-deficient or mature skin, SKNV’s Sivora Cream represents a thoughtful, prescription-only formulation designed with Estriol 0.3%, complemented by Hyaluronic Acid, Ascorbic Acid, and Aloe Vera to help support balanced hydration and rejuvenation
While various formulations address the cosmetic signs of aging, Sivora Cream is distinct in its use of Estriol, a naturally occurring mild estrogen not available in any FDA-approved 505(b) topical medication.
This prescription-only formulation brings together Estriol 0.3%, Hyaluronic Acid 0.5%, Ascorbic Acid 1%, and Aloe Vera 0.6%, offering dermatology providers a unique, clinically guided approach to addressing estrogen-deficient skin.
By combining these ingredients, Sivora Cream supports skin hydration, elasticity, and antioxidant protection — key considerations for mature skin health.
Estriol is a bioidentical estrogen known for its regenerative and anti-inflammatory effects in the skin.
By binding to estrogen receptors, Estriol can help stimulate collagen production, enhance elasticity, and improve hydration in estrogen-deficient skin.
Its mild profile allows localized benefit with limited systemic impact, making it a meaningful inclusion for topical, prescriber-directed formulations.
Hyaluronic Acid acts as a powerful humectant, drawing moisture into the skin to improve hydration and suppleness.
In Sivora Cream, it supports Estriol’s structural effects by maintaining a hydrated environment that enhances skin smoothness and resilience.
Ascorbic Acid, also known as Vitamin C, provides antioxidant protection while promoting collagen synthesis and brightening the skin.
When combined with Estriol, it contributes to a more balanced, healthy-looking complexion.
Aloe Vera offers soothing and anti-inflammatory properties, helping calm and protect the skin while reinforcing hydration and barrier integrity.
The combination of active ingredients in Sivora Cream works synergistically to target multiple pathways in estrogen-deficient and mature skin:
Together, these ingredients create a balanced, physician-directed formulation that supports hydration, elasticity, and visible rejuvenation in hormonally affected skin.
Sivora Cream offers prescribers flexibility beyond standard topical treatments.
No FDA-approved 505(b) medication combines Estriol 0.3% with Hyaluronic Acid, Ascorbic Acid, and Aloe Vera at these concentrations, making Sivora Cream a clinically differentiated option for patient-specific therapeutic needs.
It may be considered appropriate when:
SKNV is an FDA-Registered 503B Outsourcing Facility focused on supporting dermatology practices with clinically differentiated, high-quality medications.
Each formulation is produced under rigorous quality standards to empower prescribers to offer personalized, evidence-guided treatments that meet individual patient needs.
Sivora Cream reflects SKNV’s mission to advance provider-controlled, clinically guided dermatologic innovationthrough thoughtful formulation and professional precision.
Sivora Cream demonstrates SKNV’s ongoing commitment to clinically driven innovation in dermatology.
Featuring Estriol 0.3% along with Hyaluronic Acid, Ascorbic Acid, and Aloe Vera, it offers prescribers a prescription-only option to support estrogen-deficient skin and the visible signs of aging.
Through its intentional ingredient design, Sivora Cream provides a balanced, professional approach for addressing patient-specific skin concerns under clinical supervision.
If you’re a dermatology provider interested in offering Sivora Cream to your patients, contact the SKNV Provider Support Team to learn more about prescribing and dispensing.
SKNV offers educational and operational support to help practices integrate clinically differentiated medications into dermatologic care.
If you are experiencing visible changes in skin texture, dryness, or fine lines, consult your licensed healthcare provider to determine whether Sivora Cream may be appropriate for your treatment plan.
Sivora Cream is available by prescription only and must be prescribed and dispensed through a licensed healthcare professional.
Sivora Cream is a prescription-only medication manufactured by SKNV LLC, an FDA-Registered 503B Outsourcing Facility.
The FDA does not review or approve medications made by outsourcing facilities for safety, efficacy, quality, or indications for use.
A prescriber must determine, for each individual patient, whether Sivora Cream produces a clinical difference compared to a commercially available product.
Sivora Cream and its active pharmaceutical ingredients have not been reviewed or approved by the FDA for safety, efficacy, quality, or indications for use.
Sivora Cream is exempted from the clinical trials required for approved drugs.
SKNV makes no claim that Sivora Cream or its ingredients are safer or more effective than FDA-approved drugs.
SKNV makes no claim that Sivora Cream or its ingredients will not be allergens or irritants for certain patients.
