• Topical use only: Instruct patients that Kefunova Cream is for external use on the skin only. They should use the medication exactly as prescribed and avoid applying it to any area not directed by their provider.
• Avoid mucous membranes: Advise patients not to apply the cream to mucous membranes (e.g., inside the nose, mouth, or genitals) as it may cause local irritation, inflammation, or ulceration. Inform patients of potential risks during pregnancy, including reported cases of miscarriage and birth defects when fluorouracil has been applied to these areas.
• Keep away from pets: Emphasize that the medication may be fatal if ingested by pets. Patients should ensure pets do not come into contact with the tube, their skin after application, or any surfaces where the cream may have transferred.
• Proper cleanup and disposal: Educate patients on the importance of discarding or thoroughly cleaning any cloths or applicators used to apply the medication. They should also avoid leaving residues of Kefunova Cream on their hands, clothing, furniture, or carpets to prevent accidental exposure.

This formulation should be handled with care. Store it in a cool, dry, and dark place, away from direct sunlight and out of reach of pets.

Fluorouracil may cause fetal harm when administered to a pregnant woman. Fluorouracil should not be used in patients with dihydropyrimidine dehydrogenase (DPD) enzyme deficiency.  Kefunova Cream is contraindicated in patients with known hypersensitivity to any of the components contained in this product. Use with caution in patients with known drug sensitivities. Local site reactions such as application site redness, application site irritation, local skin exfoliation, application site itchiness, application site burning, local desquamation may be a sign of adverse reactions. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away.

May be fatal to pets if licked or ingested. Keep pets away from the container and any areas of skin where the medication has been applied.

Occlusion of the skin with resultant hydration has been shown to increase percutaneous penetration of several topical preparations. If any occlusive dressing is used in treatment of basal cell carcinoma, there may be an increase in the severity of inflammatory reactions in the adjacent normal skin. A porous gauze dressing may be applied for cosmetic reasons without increase in reaction.

Exposure to ultraviolet rays should be minimized during and immediately following treatment because the intensity of the reaction may be increased.

Patients may have an allergic reaction to any of the ingredients in this custom-formulated preparation. It is advisable to first test the preparation before applying it to a larger area of the body. Apply a very small amount of medication on a quarter-sized area on the forearm to test. Allow the medication to stay for about 30 minutes. If a fast reaction type of allergy occurs, the area will be red and itchy. If a slow reaction type of allergy occurs, the same symptoms may occur after 48 hours. If any of these situations occur, stop using the preparation and call your healthcare practitioner. The absence of any reaction to this test is no guarantee that an allergic reaction may not occur during future uses of this preparation.

When Kefunova Cream is used concomitantly with other products containing: 5-Fluorouracil, Calcipotriene. the total dose contributed by all formulations must be kept in mind. The amount absorbed is determined by the area over which it is applied and the duration of application.